Ontology highlight
ABSTRACT:
SUBMITTER: Lin SH
PROVIDER: S-EPMC3399418 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lin Shu-Hsi SH Yoshimoto Miwa M Lyu Ping-Chiang PC Tang Chuan-Yi CY Arita Masanori M
Evolutionary bioinformatics online 20120704
Aspergillus species are industrially and agriculturally important as fermentors and as producers of various secondary metabolites. Among them, fungal polyketides such as lovastatin and melanin are considered a gold mine for bioactive compounds. We used a phylogenomic approach to investigate the distribution of iterative polyketide synthases (PKS) in eight sequenced Aspergilli and classified over 250 fungal genes. Their genealogy by the conserved ketosynthase (KS) domain revealed three large grou ...[more]