Ontology highlight
ABSTRACT:
SUBMITTER: McKenna ES
PROVIDER: S-EPMC3359122 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
McKenna Elizabeth S ES Tamayo Pablo P Cho Yoon-Jae YJ Tillman Erik J EJ Mora-Blanco E Lorena EL Sansam Courtney G CG Koellhoffer Edward C EC Pomeroy Scott L SL Roberts Charles W M CW
Cell cycle (Georgetown, Tex.) 20120515 10
Emerging evidence demonstrates that subunits of the SWI/SNF chromatin remodeling complex are specifically mutated at high frequency in a variety of human cancer types. SNF5 (SMARCB1/INI1/BAF47), a core subunit of the SWI/SNF complex, is inactivated in the vast majority of rhabdoid tumors (RT), an aggressive type of pediatric cancer. SNF5-deficient cancers are diploid and genomically stable, suggesting that epigenetically based changes in transcription are key drivers of tumor formation caused by ...[more]