Ontology highlight
ABSTRACT:
SUBMITTER: Cui Y
PROVIDER: S-EPMC2500176 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Cui Yan Y Ying Ying Y van Hasselt Andrew A Ng Ka Man KM Yu Jun J Zhang Qian Q Jin Jie J Liu Dingxie D Rhim Johng S JS Rha Sun Young SY Loyo Myriam M Chan Anthony T C AT Srivastava Gopesh G Tsao George S W GS Sellar Grant C GC Sung Joseph J Y JJ Sidransky David D Tao Qian Q
PloS one 20080820 8
<h4>Background</h4>Identification of tumor suppressor genes (TSGs) silenced by CpG methylation uncovers the molecular mechanism of tumorigenesis and potential tumor biomarkers. Loss of heterozygosity at 11q25 is common in multiple tumors including nasopharyngeal carcinoma (NPC). OPCML, located at 11q25, is one of the downregulated genes we identified through digital expression subtraction.<h4>Methodology/principal findings</h4>Semi-quantitative RT-PCR showed frequent OPCML silencing in NPC and o ...[more]