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Amination of allylic alcohols in water at room temperature.

ABSTRACT: The "trick" to carrying out regiocontrolled aminations of allylic alcohols in water as the only medium is use of a nanomicelle's interior as the organic reaction solvent. When HCO(2)Me is present, along with the proper base and source of catalytic Pd, allylic amines are cleanly formed at room temperature.

SUBMITTER: Nishikata T

PROVIDER: S-EPMC3359138 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Amination of allylic alcohols in water at room temperature.

Nishikata Takashi T Lipshutz Bruce H BH

Organic letters 20090601 11

The "trick" to carrying out regiocontrolled aminations of allylic alcohols in water as the only medium is use of a nanomicelle's interior as the organic reaction solvent. When HCO(2)Me is present, along with the proper base and source of catalytic Pd, allylic amines are cleanly formed at room temperature. ...[more]

PMID: 19402681

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