Ontology highlight
ABSTRACT:
SUBMITTER: Xu G
PROVIDER: S-EPMC3359740 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Xu Guoshuang G Liu Kai K Anderson Judy J Patrene Kenneth K Lentzsch Suzanne S Roodman G David GD Ouyang Hongjiao H
Blood 20120316 18
BM stromal cells (BMSCs) are key players in the microenvironmental support of multiple myeloma (MM) cell growth and bone destruction. A spliced form of the X-box-binding protein-1 (XBP1s), a major proximal effector of unfolded protein response signaling, is highly expressed in MM cells and plays an indispensable role in MM pathogenesis. In the present study, we found that XBP1s is induced in the BMSCs of the MM microenvironment. XBP1s overexpression in healthy human BMSCs enhanced gene and/or pr ...[more]