Ontology highlight
ABSTRACT:
SUBMITTER: Hasan S
PROVIDER: S-EPMC3360144 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Hasan Sibah S Santhi Nayantara N Lazar Alpar S AS Slak Ana A Lo June J von Schantz Malcolm M Archer Simon N SN Johnston Jonathan D JD Dijk Derk-Jan DJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120227 6
We compared the period of the rhythm of plasma melatonin, driven by the hypothalamic circadian pacemaker, to in vitro periodicity in cultured peripheral fibroblasts to assess the effects on these rhythms of a polymorphism of PER3 (rs57875989), which is associated with sleep timing. In vitro circadian period was determined using luminometry of cultured fibroblasts, in which the expression of firefly luciferase was driven by the promoter of the circadian gene Arntl (Bmal1). The period of the melat ...[more]