Ontology highlight
ABSTRACT:
SUBMITTER: Stein RM
PROVIDER: S-EPMC7134359 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Stein Reed M RM Kang Hye Jin HJ McCorvy John D JD Glatfelter Grant C GC Jones Anthony J AJ Che Tao T Slocum Samuel S Huang Xi-Ping XP Savych Olena O Moroz Yurii S YS Stauch Benjamin B Johansson Linda C LC Cherezov Vadim V Kenakin Terry T Irwin John J JJ Shoichet Brian K BK Roth Bryan L BL Dubocovich Margarita L ML
Nature 20200210 7800
The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT<sub>1</sub> and MT<sub>2</sub>. Circadian release of melatonin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of the hypothalamus, synchronizing the physiology and behaviour of animals to the light-dark cycle<sup>1-4</sup>. The two receptors are established drug targets for aligning circadian phase ...[more]