Ontology highlight
ABSTRACT:
SUBMITTER: Ramirez AH
PROVIDER: S-EPMC3361510 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Ramirez Andrea H AH Shi Yaping Y Schildcrout Jonathan S JS Delaney Jessica T JT Xu Hua H Oetjens Matthew T MT Zuvich Rebecca L RL Basford Melissa A MA Bowton Erica E Jiang Min M Speltz Peter P Zink Raquel R Cowan James J Pulley Jill M JM Ritchie Marylyn D MD Masys Daniel R DR Roden Dan M DM Crawford Dana C DC Denny Joshua C JC
Pharmacogenomics 20120213 4
<h4>Aim</h4>Warfarin pharmacogenomic algorithms reduce dosing error, but perform poorly in non-European-Americans. Electronic health record (EHR) systems linked to biobanks may allow for pharmacogenomic analysis, but they have not yet been used for this purpose.<h4>Patients & methods</h4>We used BioVU, the Vanderbilt EHR-linked DNA repository, to identify European-Americans (n = 1022) and African-Americans (n = 145) on stable warfarin therapy and evaluated the effect of 15 pharmacogenetic varian ...[more]