Ontology highlight
ABSTRACT:
SUBMITTER: Thota S
PROVIDER: S-EPMC3361754 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Thota Sammaiah S Wang Min M Jeon Seaho S Maragani Satyanarayana S Hamblin Michael R MR Chiang Long Y LY
Molecules (Basel, Switzerland) 20120507 5
We designed and synthesized two analogous pentacationic [60]fullerenyl monoadducts, C₆₀(>ME₁N₆⁺C₃) (1) and C₆₀(>ME₃N₆⁺C₃) (2), with variation of the methoxyethyleneglycol length. Each of these derivatives bears a well-defined number of cationic charges aimed to enhance and control their ability to target pathogenic Gram-positive and Gram-negative bacterial cells for allowing photodynamic inactivation. The synthesis was achieved by the use of a common synthon of pentacationic N,N′,N,N,N,N-hexapro ...[more]