Ontology highlight
ABSTRACT:
SUBMITTER: Vagin O
PROVIDER: S-EPMC3361946 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Vagin Olga O Dada Laura A LA Tokhtaeva Elmira E Sachs George G
American journal of physiology. Cell physiology 20120125 9
The ion gradients generated by the Na-K-ATPase play a critical role in epithelia by driving transepithelial transport of various solutes. The efficiency of this Na-K-ATPase-driven vectorial transport depends on the integrity of epithelial junctions that maintain polar distribution of membrane transporters, including the basolateral sodium pump, and restrict paracellular diffusion of solutes. The review summarizes the data showing that, in addition to pumping ions, the Na-K-ATPase located at the ...[more]