Ontology highlight
ABSTRACT:
SUBMITTER: Verdoes M
PROVIDER: S-EPMC3361968 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Verdoes Martijn M Edgington Laura E LE Scheeren Ferenc A FA Leyva Melissa M Blum Galia G Weiskopf Kipp K Bachmann Michael H MH Ellman Jonathan A JA Bogyo Matthew M
Chemistry & biology 20120501 5
Macrophage infiltration into tumors has been correlated with poor clinical outcome in multiple cancer types. Therefore, tools to image tumor-associated macrophages could be valuable for diagnosis and prognosis of cancer. Herein, we describe the synthesis and characterization of a cathepsin S-directed, quenched activity-based probe (qABP), BMV083. This probe makes use of an optimized nonpeptidic scaffold leading to enhanced in vivo properties relative to previously reported peptide-based probes. ...[more]