Ontology highlight
ABSTRACT:
SUBMITTER: Romero Pastrana F
PROVIDER: S-EPMC5955194 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Virulence 20171226 1
Staphylococcus aureus infections are a major threat in healthcare, requiring adequate early-stage diagnosis and treatment. This calls for novel diagnostic tools that allow noninvasive in vivo detection of staphylococci. Here we performed a preclinical study to investigate a novel fully-human monoclonal antibody 1D9 that specifically targets the immunodominant staphylococcal antigen A (IsaA). We show that 1D9 binds invariantly to S. aureus cells and may further target other staphylococcal species ...[more]