Ontology highlight
ABSTRACT:
SUBMITTER: Prodduturi P
PROVIDER: S-EPMC3362327 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Clinical Medicine Insights. Oncology 20120521
Primary central nervous system lymphoma (PCNSL) constitutes a rare group of extranodal non-Hodgkin's lymphoma (NHL) primarily of B cell origin. It occurs in both immuno-competent and immune-compromised patients. High dose m ethotrexate (HD-MTX) based chemotherapy is the standard therapy. Chemotherapy with whole brain radiation therapy (WBRT) improves response rates and survival compared with WBRT alone. However, due to the increased risk for neurotoxicity with WBRT, recent studies have focused o ...[more]