Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties.
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ABSTRACT:
SUBMITTER: Irimia M
PROVIDER: S-EPMC3364491 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties.
Irimia Manuel M Royo Jose L JL Burguera Demian D Maeso Ignacio I Gómez-Skarmeta José L JL Garcia-Fernandez Jordi J
Scientific reports 20120531
The origin and evolution of the complex regulatory landscapes of some vertebrate developmental genes, often spanning hundreds of Kbp and including neighboring genes, remain poorly understood. The Sonic Hedgehog (Shh) genomic regulatory block (GRB) is one of the best functionally characterized examples, with several discrete enhancers reported within its introns, vast upstream gene-free region and neighboring genes (Lmbr1 and Rnf32). To investigate the origin and evolution of this GRB, we sequenc ...[more]
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