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Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae.


ABSTRACT: Shewanella algae is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in S. algae. In this study, we aim to determine the occurrence of common virulence genes in S. algae using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to bile resistance, chemotaxis, hemolysis, and motility. We detected the existence of hlyA, hlyD, and hlyIII involved in hemolysis. We also found chemotaxis gene cluster cheYZA operon and cheW gene. The results provide insights into the genetic basis underlying pathogenicity in S. algae.

SUBMITTER: Wang JH 

PROVIDER: S-EPMC7149415 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Comparative Genomics Reveals Pathogenicity-Related Loci in <i>Shewanella algae</i>.

Wang Jui-Hsing JH   He Guo-Cheng GC   Huang Yao-Ting YT   Liu Po-Yu PY  

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale 20200330


<i>Shewanella algae</i> is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in <i>S. algae</i>. In this study, we aim to determine the occurrence of common virulence genes in <i>S. algae</i> using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to b  ...[more]

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