Ontology highlight
ABSTRACT:
SUBMITTER: Cruz-Migoni A
PROVIDER: S-EPMC3364511 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cruz-Migoni Abimael A Hautbergue Guillaume M GM Artymiuk Peter J PJ Baker Patrick J PJ Bokori-Brown Monika M Chang Chung-Te CT Dickman Mark J MJ Essex-Lopresti Angela A Harding Sarah V SV Mahadi Nor Muhammad NM Marshall Laura E LE Mobbs George W GW Mohamed Rahmah R Nathan Sheila S Ngugi Sarah A SA Ong Catherine C Ooi Wen Fong WF Partridge Lynda J LJ Phillips Helen L HL Raih M Firdaus MF Ruzheinikov Sergei S Sarkar-Tyson Mitali M Sedelnikova Svetlana E SE Smither Sophie J SJ Tan Patrick P Titball Richard W RW Wilson Stuart A SA Rice David W DW
Science (New York, N.Y.) 20111101 6057
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase ac ...[more]