Ontology highlight
ABSTRACT:
SUBMITTER: Nakae J
PROVIDER: S-EPMC3364737 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Nakae Jun J Cao Yongheng Y Hakuno Fumihiko F Takemori Hiroshi H Kawano Yoshinaga Y Sekioka Risa R Abe Takaya T Kiyonari Hiroshi H Tanaka Toshiya T Sakai Juro J Takahashi Shin-Ichiro S Itoh Hiroshi H
The EMBO journal 20120417 10
Forkhead box-containing protein o (Foxo) 1 is a key transcription factor in insulin and glucose metabolism. We identified a Foxo1-CoRepressor (FCoR) protein in mouse adipose tissue that inhibits Foxo1's activity by enhancing acetylation via impairment of the interaction between Foxo1 and the deacetylase Sirt1 and via direct acetylation. FCoR is phosphorylated at Threonine 93 by catalytic subunit of protein kinase A and is translocated into nucleus, making it possible to bind to Foxo1 in both cyt ...[more]