Ontology highlight
ABSTRACT:
SUBMITTER: Stoeber M
PROVIDER: S-EPMC3364743 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Stoeber Miriam M Stoeck Ina Karen IK Hänni Christine C Bleck Christopher Karl Ernst CK Balistreri Giuseppe G Helenius Ari A
The EMBO journal 20120413 10
Caveolae are specialized domains present in the plasma membrane (PM) of most mammalian cell types. They function in signalling, membrane regulation, and endocytosis. We found that the Eps-15 homology domain-containing protein 2 (EHD2, an ATPase) associated with the static population of PM caveolae. Recruitment to the PM involved ATP binding, interaction with anionic lipids, and oligomerization into large complexes (60-75S) via interaction of the EH domains ...[more]