Ontology highlight
ABSTRACT:
SUBMITTER: Hoernke M
PROVIDER: S-EPMC5465919 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hoernke Maria M Mohan Jagan J Larsson Elin E Blomberg Jeanette J Kahra Dana D Westenhoff Sebastian S Schwieger Christian C Lundmark Richard R
Proceedings of the National Academy of Sciences of the United States of America 20170221 22
The EH-domain-containing protein 2 (EHD2) is a dynamin-related ATPase that confines caveolae to the cell surface by restricting the scission and subsequent endocytosis of these membrane pits. For this, EHD2 is thought to first bind to the membrane, then to oligomerize, and finally to detach, in a stringently regulated mechanistic cycle. It is still unclear how ATP is used in this process and whether membrane binding is coupled to conformational changes in the protein. Here, we show that the regu ...[more]