Ontology highlight
ABSTRACT:
SUBMITTER: Willinger T
PROVIDER: S-EPMC3365213 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Willinger Tim T Flavell Richard A RA
Proceedings of the National Academy of Sciences of the United States of America 20120516 22
The homeostasis of naive T cells is essential for protective immunity against infection, but the cell-intrinsic molecular mechanisms that control naïve T-cell homeostasis are poorly understood. Genetic ablation in lower organisms has revealed a critical role for Vps34, an evolutionary conserved class III phosphoinositide-3 kinase (PI3K), in regulating endocytosis and autophagy; however, the physiological function of Vps34 in the immune system, especially in T cells, is unclear. Here we report th ...[more]