Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC3365218 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Wang Chunlin C Krishnakumar Sujatha S Wilhelmy Julie J Babrzadeh Farbod F Stepanyan Lilit L Su Laura F LF Levinson Douglas D Fernandez-Viña Marcelo A MA Davis Ronald W RW Davis Mark M MM Mindrinos Michael M
Proceedings of the National Academy of Sciences of the United States of America 20120515 22
Human leukocyte antigen (HLA) genes are the most polymorphic in the human genome. They play a pivotal role in the immune response and have been implicated in numerous human pathologies, especially autoimmunity and infectious diseases. Despite their importance, however, they are rarely characterized comprehensively because of the prohibitive cost of standard technologies and the technical challenges of accurately discriminating between these highly related genes and their many allelles. Here we d ...[more]