Ontology highlight
ABSTRACT:
SUBMITTER: Sakaguchi S
PROVIDER: S-EPMC3365445 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Sakaguchi Shinya S Hombauer Matthias M Bilic Ivan I Naoe Yoshinori Y Schebesta Alexandra A Taniuchi Ichiro I Ellmeier Wilfried W
Nature immunology 20100411 5
The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR negatively regulates the Cd8 loci during the transition to the double-positive (DP) stage. Moreover, loss of MAZR led to partial redirection of major histocompatibility complex (MHC) ...[more]