Unknown

Dataset Information

0

The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.


ABSTRACT: Type I invariant NKT cells (iNKT cells) are a subset of alphabeta T cells characterized by the expression of an invariant alpha-chain variable region 14-alpha-chain joining region 18 (V(alpha)14J(alpha)18) T cell antigen receptor (TCR) alpha-chain. The iNKT cells derive from CD4(+)CD8(+) double-positive (DP) thymocytes, and their generation requires a long half-life of DP thymocytes to allow V(alpha)14-J(alpha)18 rearrangements, expression of glycolipid-loaded CD1d on DP thymocytes, and signaling through the signaling-activation molecule SLAM-adaptor SAP pathway. Here we show that the transcription factor c-Myb has a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, the half-life of DP cells and expression of SLAMF1, SLAMF6 and SAP.

SUBMITTER: Hu T 

PROVIDER: S-EPMC2857587 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.

Hu Taishan T   Simmons Amie A   Yuan Joan J   Bender Timothy P TP   Alberola-Ila Jose J  

Nature immunology 20100411 5


Type I invariant NKT cells (iNKT cells) are a subset of alphabeta T cells characterized by the expression of an invariant alpha-chain variable region 14-alpha-chain joining region 18 (V(alpha)14J(alpha)18) T cell antigen receptor (TCR) alpha-chain. The iNKT cells derive from CD4(+)CD8(+) double-positive (DP) thymocytes, and their generation requires a long half-life of DP thymocytes to allow V(alpha)14-J(alpha)18 rearrangements, expression of glycolipid-loaded CD1d on DP thymocytes, and signalin  ...[more]

Similar Datasets

| S-EPMC6338460 | biostudies-literature
| S-EPMC2942964 | biostudies-literature
| S-EPMC2670481 | biostudies-literature
| S-EPMC2856624 | biostudies-literature
| S-EPMC3365445 | biostudies-literature
| S-EPMC6053179 | biostudies-literature
| S-EPMC2912293 | biostudies-literature
| S-EPMC1949015 | biostudies-literature
| S-EPMC3930506 | biostudies-literature
| S-EPMC1570435 | biostudies-literature