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Total synthesis of piericidin A1. Application of a modified Negishi carboalumination-nickel-catalyzed cross-coupling.

ABSTRACT: A total synthesis of the mitochondrial complex I inhibitor piericidin A1 is described. It features a unique strategy for the key disconnection, highlighting a modified Negishi carboalumination/Ni-catalyzed cross-coupling on a polyenyne precursor.

SUBMITTER: Lipshutz BH

PROVIDER: S-EPMC3365511 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Total synthesis of piericidin A1. Application of a modified Negishi carboalumination-nickel-catalyzed cross-coupling.

Lipshutz Bruce H BH Amorelli Benjamin B

Journal of the American Chemical Society 20090201 4

A total synthesis of the mitochondrial complex I inhibitor piericidin A1 is described. It features a unique strategy for the key disconnection, highlighting a modified Negishi carboalumination/Ni-catalyzed cross-coupling on a polyenyne precursor. ...[more]

PMID: 19138148

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