Unknown

Dataset Information

0

Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction.

ABSTRACT: We report the first example of a silyl-Negishi reaction between secondary zinc organometallics and silicon electrophiles. This palladium-catalyzed process provides direct access to alkyl silanes. The delicate balance of steric and electronic parameters of the employed DrewPhos ligand is paramount to suppressing isomerization and promoting efficient and selective cross-coupling.

SUBMITTER: Cinderella AP 

PROVIDER: S-EPMC5531279 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction.

Cinderella Andrew P AP   Vulovic Bojan B   Watson Donald A DA  

Journal of the American Chemical Society 20170601 23

We report the first example of a silyl-Negishi reaction between secondary zinc organometallics and silicon electrophiles. This palladium-catalyzed process provides direct access to alkyl silanes. The delicate balance of steric and electronic parameters of the employed DrewPhos ligand is paramount to suppressing isomerization and promoting efficient and selective cross-coupling. ...[more]

Similar Datasets

Unknown Nickel-catalyzed Negishi cross-coupling reactions of secondary alkylzinc halides and aryl iodides.
| S-EPMC6474776 | biostudies-literature
Unknown Highly selective palladium-catalyzed cross-coupling of secondary alkylzinc reagents with heteroaryl halides.
| S-EPMC4156254 | biostudies-literature
Unknown Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides.
| S-EPMC2746668 | biostudies-literature
Unknown Cobalt-Catalyzed Cross-Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides.
| S-EPMC7154687 | biostudies-literature
Unknown Highly selective reactions of unbiased alkenyl halides and alkylzinc halides: Negishi-Plus couplings.
| S-EPMC3365517 | biostudies-literature
Unknown Palladium-catalyzed allylic cross-coupling reactions of primary and secondary homoallylic electrophiles.
| S-EPMC3412144 | biostudies-other
Unknown Minimizing the amount of nitromethane in palladium-catalyzed cross-coupling with aryl halides.
| S-EPMC3778657 | biostudies-literature
Unknown Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides.
| S-EPMC5590096 | biostudies-literature
Unknown Ligand-controlled palladium-catalyzed regiodivergent Suzuki-Miyaura cross-coupling of allylboronates and aryl halides.
| S-EPMC3776608 | biostudies-literature
Unknown Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling.
| S-EPMC5539790 | biostudies-literature