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The elements of human cyclin D1 promoter and regulation involved.

ABSTRACT: Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-?B, E2F, Oct-1, and so on. The extracellular signals functions through the signal transduction pathways converging at the binding sites to active or inhibit the promoter activity and regulate the cell cycle progression. Different signal transduction pathways regulate the promoter at different time to get the correct cell cycle switch. Disorder regulation or special extracellular stimuli can result in cell cycle out of control through the promoter activity regulation. Epigenetic modifications such as DNA methylation and histone acetylation may involved in cyclin D1 transcriptional regulation.

SUBMITTER: Guo ZY

PROVIDER: S-EPMC3365593 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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The elements of human cyclin D1 promoter and regulation involved.

Guo Zhi-Yi ZY Hao Xiao-Hui XH Tan Fei-Fei FF Pei Xin X Shang Li-Mei LM Jiang Xue-Lian XL Yang Fang F

Clinical epigenetics 20110211 2

Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, and so on. The extracellular signals functions through the signal transduction pathways converging at the binding sites to active or inhibit the promoter activity and regulate the cell cycle progression. Different signal transduction pathways regulate the promo ...[more]

PMID: 22704330

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2013-12-31 | GSE43216 | GEO

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