Ontology highlight
ABSTRACT:
SUBMITTER: Vastagh C
PROVIDER: S-EPMC3365766 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Vastagh Csaba C Gardoni Fabrizio F Bagetta Vincenza V Stanic Jennifer J Zianni Elisa E Giampà Carmen C Picconi Barbara B Calabresi Paolo P Di Luca Monica M
The Journal of biological chemistry 20120409 22
Dendritic spines of medium spiny neurons represent an essential site of information processing between NMDA and dopamine receptors in striatum. Even if activation of NMDA receptors in the striatum has important implications for synaptic plasticity and disease states, the contribution of specific NMDA receptor subunits still remains to be elucidated. Here, we show that treatment of corticostriatal slices with NR2A antagonist NVP-AAM077 or with NR2A blocking peptide induces a significant increase ...[more]