Ontology highlight
ABSTRACT:
SUBMITTER: Richards OC
PROVIDER: S-EPMC3365844 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Richards Oliver C OC Raines Summer M SM Attie Alan D AD
Endocrine reviews 20100217 3
The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin must efficiently enter the bloodstream from pancreatic beta-cells, circulate throughout the body, and efficiently exit the bloodstream to reach target tissues and mediate its effects. Defects in the vasculature of pancreatic islets can lead to diabetic phenotypes. Similarly, insulin resistance is accompanied by defects in the vasculature of skeletal muscle, which ultimately reduce the ability of insulin a ...[more]