Ontology highlight
ABSTRACT:
SUBMITTER: Capel E
PROVIDER: S-EPMC5810509 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Capel Elena E Barnier Jean-Philippe JP Zomer Aldert L AL Bole-Feysot Christine C Nussbaumer Thomas T Jamet Anne A Lécuyer Hervé H Euphrasie Daniel D Virion Zoé Z Frapy Eric E Pélissier Philippe P Join-Lambert Olivier O Rattei Thomas T Bourdoulous Sandrine S Nassif Xavier X Coureuil Mathieu M
Virulence 20171127 8
Neisseria meningitidis is the causative agent of cerebrospinal meningitis and that of a rapidly progressing fatal septic shock known as purpura fulminans. Meningococcemia is characterized by bacterial adhesion to human endothelial cells of the microvessels. Host specificity has hampered studies on the role of blood vessels colonization in N. meningitidis associated pathogenesis. In this work, using a humanized model of SCID mice allowing the study of bacterial adhesion to human cells in an in vi ...[more]