Ontology highlight
ABSTRACT:
SUBMITTER: Kurouski D
PROVIDER: S-EPMC3365881 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Kurouski Dmitry D Washington Jacqueline J Ozbil Mehmet M Prabhakar Rajeev R Shekhtman Alexander A Lednev Igor K IK
PloS one 20120601 6
Amyloid fibrils are β-sheet-rich protein aggregates commonly found in the organs and tissues of patients with various amyloid-associated diseases. Understanding the structural organization of amyloid fibrils can be beneficial for the search of drugs to successfully treat diseases associated with protein misfolding. The structure of insulin fibrils was characterized by deep ultraviolet resonance Raman (DUVRR) and Nuclear Magnetic Resonance (NMR) spectroscopy combined with hydrogen-deuterium excha ...[more]