Ontology highlight
ABSTRACT:
SUBMITTER: Novotny-Diermayr V
PROVIDER: S-EPMC3366067 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Blood cancer journal 20120504 5
Acute myeloid leukemia (AML) is currently treated with aggressive chemotherapy that is not well tolerated in many elderly patients, hence the unmet medical need for effective therapies with less toxicity and better tolerability. Inhibitors of FMS-like tyrosine kinase 3 (FLT3), JAK2 and histone deacetylase inhibitors (HDACi) have been tested in clinical studies, but showed only moderate single-agent activity. High efficacy of the HDACi pracinostat treating AML and synergy with the JAK2/FLT3 inhib ...[more]