Ontology highlight
ABSTRACT:
SUBMITTER: Jeon JY
PROVIDER: S-EPMC6858927 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Jeon Jae Yoon JY Zhao Qiuhong Q Buelow Daelynn R DR Phelps Mitch M Walker Alison R AR Mims Alice S AS Vasu Sumithira S Behbehani Gregory G Blachly James J Blum William W Klisovic Rebecca B RB Byrd John C JC Garzon Ramiro R Baker Sharyn D SD Bhatnagar Bhavana B
Investigational new drugs 20190517 2
Activating FLT3 internal tandem duplication (FLT3-ITD) mutations in acute myeloid leukemia (AML) associate with inferior outcomes. We determined that pacritinib, a JAK2/FLT3 inhibitor, has in vitro activity against FLT3-ITD and tyrosine kinase domain (TKD) mutations. Therefore, we conducted a phase I study of pacritinib in combination with chemotherapy in AML patients with FLT3 mutations to determine the pharmacokinetics and preliminary toxicity and clinical activity. Pacritinib was administered ...[more]