Ontology highlight
ABSTRACT:
SUBMITTER: LaBelle JL
PROVIDER: S-EPMC3366394 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
LaBelle James L JL Katz Samuel G SG Bird Gregory H GH Gavathiotis Evripidis E Stewart Michelle L ML Lawrence Chelsea C Fisher Jill K JK Godes Marina M Pitter Kenneth K Kung Andrew L AL Walensky Loren D LD
The Journal of clinical investigation 20120524 6
Cancer cells subvert the natural balance between cellular life and death, achieving immortality through pathologic enforcement of survival pathways and blockade of cell death mechanisms. Pro-apoptotic BCL-2 family proteins are frequently disarmed in relapsed and refractory cancer through genetic deletion or interaction-based neutralization by overexpressed antiapoptotic proteins, resulting in resistance to chemotherapy and radiation treatments. New pharmacologic strategies are urgently needed to ...[more]