Ontology highlight
ABSTRACT:
SUBMITTER: Huhn AJ
PROVIDER: S-EPMC5055752 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Cell chemical biology 20160908 9
Anti-apoptotic BCL-2 family proteins block cell death by trapping the critical α-helical BH3 domains of pro-apoptotic members in a surface groove. Cancer cells hijack this survival mechanism by overexpressing a spectrum of anti-apoptotic members, mounting formidable apoptotic blockades that resist chemotherapeutic treatment. Drugging the BH3-binding pockets of anti-apoptotic proteins has become a highest-priority goal, fueled by the clinical success of ABT-199, a selective BCL-2 inhibitor, in re ...[more]