Ontology highlight
ABSTRACT:
SUBMITTER: Friedman JR
PROVIDER: S-EPMC3366560 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Friedman Jonathan R JR Lackner Laura L LL West Matthew M DiBenedetto Jared R JR Nunnari Jodi J Voeltz Gia K GK
Science (New York, N.Y.) 20110901 6054
Mitochondrial structure and distribution are regulated by division and fusion events. Mitochondrial division is regulated by Dnm1/Drp1, a dynamin-related protein that forms helices around mitochondria to mediate fission. Little is known about what determines sites of mitochondrial fission within the mitochondrial network. The endoplasmic reticulum (ER) and mitochondria exhibit tightly coupled dynamics and have extensive contacts. We tested whether ER plays a role in mitochondrial division. We fo ...[more]