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ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies.

ABSTRACT: BACKGROUND: Alcohol dehydrogenase 1C (ADH1C) is the key enzyme catalyze oxidation of alcohol to acetaldehyde, which plays vital roles in the etiology of various cancer. To date, studies investigated the association between a functional polymorphism in ADH1C, Ile350Val (rs698), and risk of cancer have shown inclusive results. METHODS: A meta-analysis based on 35 case-control studies was performed to address this issue. Odds ratios (OR) with 95% confidence intervals (CIs) were used to assess the association. The statistical heterogeneity across studies was examined with ?2-based Q-test. RESULTS: Overall, no significant associations between ADH1C Ile350Val polymorphism and cancer risk were observed in any genetic models (P>0.05). In the stratified analyses, there was a significantly increased cancer risk among African (Val/Val vs. Ile/Ile OR ?=? 2.19, 95% CI ?=? 1.29-3.73, P(heterogeneity) ?= ?0.989; Ile/Val + Val/Val vs. Ile/Ile: OR ?=? 1.79, 95%CI ?= ?1.18-2.71, P(heterogeneity) ?= ?0.761; Val/Val vs. Ile/Val + Ile/Ile: OR ?=? 1.92, 95% CI ?= ?1.16-3.17, P(heterogeneity) ?= ?0.981) and Asian (Ile/Val vs. Ile/Ile: OR ?=? 1.58, 95% CI ?=? 1.32-1.90, P(heterogeneity) ?=? 0.375; Val/Val vs. Ile/Ile: OR ?=? 3.84, 95% CI ?= ?1.74-8.49, P(heterogeneity) ?= ?0.160; Ile/Val + Val/Val vs. Ile/Ile: OR ?=? 1.65, 95% CI ?= ?1.38-1.96, P(heterogeneity) ?=? 0.330; Val/Val vs. Ile/Val + Ile/Ile: OR ?=? 3.54, 95% CI ?= ?1.62-7.75, P(heterogeneity) ?=? 0.154) studies. CONCLUSIONS: The results indicate that ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians. Additional comprehensive system analyses are required to validate this association combined with other related polymorphisms.

SUBMITTER: Xue Y

PROVIDER: S-EPMC3366713 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies.

Xue Yao Y Wang Meilin M Zhong Dongyan D Tong Na N Chu Haiyan H Sheng Xiaojing X Zhang Zhengdong Z

PloS one 20120518 5

<h4>Background</h4>Alcohol dehydrogenase 1C (ADH1C) is the key enzyme catalyze oxidation of alcohol to acetaldehyde, which plays vital roles in the etiology of various cancer. To date, studies investigated the association between a functional polymorphism in ADH1C, Ile350Val (rs698), and risk of cancer have shown inclusive results.<h4>Methods</h4>A meta-analysis based on 35 case-control studies was performed to address this issue. Odds ratios (OR) with 95% confidence intervals (CIs) were used to ...[more]

PMID: 22675424

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Project description:BACKGROUND: MicroRNAs (miRNAs) are a family of endogenous, small and non-coding RNAs that regulate gene expression negatively at the post-transcriptional level by suppressing translation or degrading target mRNAs, and are involved in diverse biological and pathological processes. Single nucleotide polymorphisms (SNPs) which are located in the miRNA-coding genes may participate in the process of development and diseases by altering the expression of mature miRNA. Recent studies investigating the association between hsa-mir-499 polymorphism (rs3746444) and cancer risk have yielded conflicting results. METHODS: In this meta-analysis, we conducted a search of case-control studies on the associations of SNP rs3746444 with susceptibility to cancer in electronic databases. A total of 31 studies involving 12799 cases and 14507 controls were retrieved and the strength of the association was estimated by pooled odds ratios (ORs) and 95% confidence intervals (CIs). Hardy-Weinberg equilibrium (HWE) was assessed by the goodness-of-fit chi-square test in controls. Subgroup analyses were done by racial descent and cancer type. Publication bias of literatures was evaluated by visual inspection of funnel plots and the linear regression asymmetry test by Egger et al. Sensitivity analysis was conducted by excluding one study at a time to examine the influence of individual data set on the pooled ORs. RESULTS: Overall, significant association between rs3746444 polymorphism and susceptibility to cancer was identified in TC versus TT and TC/CC versus TT (dominant) models. In the stratified analyses, increased risks were found in Asians, but not in Caucasians in all comparison models tested. Moreover, significant association with an increased risk was found in Chinese population. Also, much higher significant association with increased cancer risks were found in Iranian population. In different cancer types, a decreased risk was found in esophageal cancer. CONCLUSION: Our meta-analysis suggested that hsa-mir-499 rs3746444 T > C polymorphism is associated with the risk of cancer in Asians, mainly in Iranian and Chinese population. However, rs3746444 T > C polymorphism is negatively associated with the risk of esophageal cancer.

Dataset Information

ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies.

Publications

ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies.

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