Ontology highlight
ABSTRACT:
SUBMITTER: Soares da Costa TP
PROVIDER: S-EPMC3366794 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Soares da Costa Tatiana P TP Tieu William W Yap Min Y MY Pendini Nicole R NR Polyak Steven W SW Sejer Pedersen Daniel D Morona Renato R Turnidge John D JD Wallace John C JC Wilce Matthew C J MCJ Booker Grant W GW Abell Andrew D AD
The Journal of biological chemistry 20120321 21
There is a well documented need to replenish the antibiotic pipeline with new agents to combat the rise of drug resistant bacteria. One strategy to combat resistance is to discover new chemical classes immune to current resistance mechanisms that inhibit essential metabolic enzymes. Many of the obvious drug targets that have no homologous isozyme in the human host have now been investigated. Bacterial drug targets that have a closely related human homologue represent a new frontier in antibiotic ...[more]