Ontology highlight
ABSTRACT:
SUBMITTER: Galichon P
PROVIDER: S-EPMC3367202 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Galichon Pierre P Mesnard Laurent L Hertig Alexandre A Stengel Bénédicte B Rondeau Eric E
Nucleic acids research 20120222 11
Genome-wide association studies (GWAS) have become a preferred method to identify new genetic susceptibility loci. This technique aims to understanding the molecular etiology of common diseases, but in many cases, it has led to the identification of loci with no obvious biological relevance. Herein, we show that previously unrecognized sequence homologies have caused single-nucleotide polymorphism (SNP) microarrays to incorrectly associate a phenotype to a given locus when in fact the linkage is ...[more]