Ontology highlight
ABSTRACT:
SUBMITTER: Barish GD
PROVIDER: S-EPMC3367511 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Cell metabolism 20120329 4
Chronic inflammation is a hallmark of atherosclerosis, but its transcriptional underpinnings are poorly understood. We show that the transcriptional repressor Bcl6 is an anti-inflammatory regulator whose loss in bone marrow of Ldlr(-/-) mice results in severe atherosclerosis and xanthomatous tendonitis, a virtually pathognomonic complication in patients with familial hypercholesterolemia. Disruption of the interaction between Bcl6 and SMRT or NCoR with a peptide inhibitor in vitro recapitulated ...[more]