Ontology highlight
ABSTRACT:
SUBMITTER: Oberoi J
PROVIDER: S-EPMC3232451 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20110116 2
Eukaryotic transcriptional repressors function by recruiting large coregulatory complexes that target histone deacetylase enzymes to gene promoters and enhancers. Transcriptional repression complexes, assembled by the corepressor NCoR and its homolog SMRT, are crucial in many processes, including development and metabolic physiology. The core repression complex involves the recruitment of three proteins, HDAC3, GPS2 and TBL1, to a highly conserved repression domain within SMRT and NCoR. We have ...[more]