Ontology highlight
ABSTRACT:
SUBMITTER: Wu MY
PROVIDER: S-EPMC3367527 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Cell research 20120320 6
SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identified macrophage migration inhibitory factor (MIF) as a novel target gene of SRC-3 and demonstrated its importance in cell survival. Specifically, we showed that MIF is a strong suppres ...[more]