Ontology highlight
ABSTRACT:
SUBMITTER: Lee JP
PROVIDER: S-EPMC4922441 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Autophagy 20160510 6
MIF (macrophage migration inhibitory factor [glycosylation-inhibiting factor]) is a pro-inflammatory cytokine expressed in multiple cells types, including macrophages. MIF plays a pathogenic role in a number of inflammatory diseases and has been linked to tumor progression in some cancers. Previous work has demonstrated that loss of autophagy in macrophages enhances secretion of IL1 family cytokines. Here, we demonstrate that loss of autophagy, by pharmacological inhibition or siRNA silencing of ...[more]