Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3368235 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Wang Xiaoreng X Liu Xiuhua X Wang Song S Luan Kang K
Hypertension research : official journal of the Japanese Society of Hypertension 20120315 6
Human myofibrillogenesis regulator 1, a novel 17-kDa protein, is closely involved in cardiac hypertrophy. We studied the molecular mechanism that links MR-1 to hypertrophic response. Hypertrophic hallmarks such as cell size and [(3)H]-leucine incorporation were significantly increased when MR-1 was transfected into cardiomyocytes for 48 h. However, sarcomere organization was promoted when MR-1 was transfected for 8 h. The finding that cardiac hypertrophy was induced long after increase of sarcom ...[more]