Ontology highlight
ABSTRACT:
SUBMITTER: Smibert P
PROVIDER: S-EPMC3368434 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Smibert Peter P Miura Pedro P Westholm Jakub O JO Shenker Sol S May Gemma G Duff Michael O MO Zhang Dayu D Eads Brian D BD Carlson Joe J Brown James B JB Eisman Robert C RC Andrews Justen J Kaufman Thomas T Cherbas Peter P Celniker Susan E SE Graveley Brenton R BR Lai Eric C EC
Cell reports 20120301 3
We analyzed the usage and consequences of alternative cleavage and polyadenylation (APA) in Drosophila melanogaster by using >1 billion reads of stranded mRNA-seq across a variety of dissected tissues. Beyond demonstrating that a majority of fly transcripts are subject to APA, we observed broad trends for 3' untranslated region (UTR) shortening in the testis and lengthening in the central nervous system (CNS); the latter included hundreds of unannotated extensions ranging up to 18 kb. Extensive ...[more]