Ontology highlight
ABSTRACT:
SUBMITTER: Louie RK
PROVIDER: S-EPMC3368710 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Louie Ryan K RK Bahmanyar Shirin S Siemers Kathleen A KA Votin Violet V Chang Paul P Stearns Tim T Nelson W James WJ Barth Angela I M AI
Journal of cell science 20040217 Pt 7
Adenomatous polyposis coli (APC) and End-binding protein 1 (EB1) localize to centrosomes independently of cytoplasmic microtubules (MTs) and purify with centrosomes from mammalian cell lines. Localization of EB1 to centrosomes is independent of its MT binding domain and is mediated by its C-terminus. Both APC and EB1 preferentially localize to the mother centriole and EB1 forms a cap at the end of the mother centriole that contains the subdistal appendages as defined by epsilon-tubulin localizat ...[more]