Ontology highlight
ABSTRACT:
SUBMITTER: Mohr H
PROVIDER: S-EPMC3369935 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Mohr Hermine H Mohr Christian A CA Schneider Marlon R MR Scrivano Laura L Adler Barbara B Kraner-Schreiber Simone S Schnieke Angelika A Dahlhoff Maik M Wolf Eckhard E Koszinowski Ulrich H UH Ruzsics Zsolt Z
PLoS pathogens 20120607 6
There is increasing evidence for a connection between DNA replication and the expression of adjacent genes. Therefore, this study addressed the question of whether a herpesvirus origin of replication can be used to activate or increase the expression of adjacent genes. Cell lines carrying an episomal vector, in which reporter genes are linked to the murine cytomegalovirus (MCMV) origin of lytic replication (oriLyt), were constructed. Reporter gene expression was silenced by a histone-deacetylase ...[more]