Ontology highlight
ABSTRACT:
SUBMITTER: Johnson K
PROVIDER: S-EPMC3370098 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Johnson Kristen K Chaumeil Julie J Micsinai Mariann M Wang Joy M H JM Ramsey Laura B LB Baracho Gisele V GV Rickert Robert C RC Strino Francesco F Kluger Yuval Y Farrar Michael A MA Skok Jane A JA
Journal of immunology (Baltimore, Md. : 1950) 20120511 12
Ag receptor diversity involves the introduction of DNA double-stranded breaks during lymphocyte development. To ensure fidelity, cleavage is confined to the G(0)-G(1) phase of the cell cycle. One established mechanism of regulation is through periodic degradation of the RAG2 recombinase protein. However, there are additional levels of protection. In this paper, we show that cyclical changes in the IL-7R signaling pathway functionally segregate pro-B cells according to cell cycle status. In conse ...[more]