Ontology highlight
ABSTRACT:
SUBMITTER: Koshiji M
PROVIDER: S-EPMC404317 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Koshiji Minori M Kageyama Yukio Y Pete Erin A EA Horikawa Izumi I Barrett J Carl JC Huang L Eric LE
The EMBO journal 20040408 9
Hypoxia induces angiogenesis and glycolysis for cell growth and survival, and also leads to growth arrest and apoptosis. HIF-1alpha, a basic helix-loop-helix PAS transcription factor, acts as a master regulator of oxygen homeostasis by upregulating various genes under low oxygen tension. Although genetic studies have indicated the requirement of HIF-1alpha for hypoxia-induced growth arrest and activation of p21(cip1), a key cyclin-dependent kinase inhibitor controlling cell cycle checkpoint, the ...[more]