Ontology highlight
ABSTRACT:
SUBMITTER: Kiselev E
PROVIDER: S-EPMC3370419 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Kiselev Evgeny E Empey Nicholas N Agama Keli K Pommier Yves Y Cushman Mark M
The Journal of organic chemistry 20120515 11
Dibenzo[c,h][1,5]naphthyridinediones were prepared via a novel synthetic pathway. The compounds were designed as topoisomerase I (Top1) inhibitors based on the indenoisoquinoline series of drugs. The results of biological evaluation demonstrate that, unlike very closely related dibenzo[c,h][1,6]naphthyridinediones, dibenzo[c,h][1,5]naphthyridinediones retain the Top1 inhibitory activity of similarly substituted indenoisoquinolines. ...[more]