Unknown

Dataset Information

0

Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation.


ABSTRACT: Dibenzo[c,h][1,5]naphthyridinediones were prepared via a novel synthetic pathway. The compounds were designed as topoisomerase I (Top1) inhibitors based on the indenoisoquinoline series of drugs. The results of biological evaluation demonstrate that, unlike very closely related dibenzo[c,h][1,6]naphthyridinediones, dibenzo[c,h][1,5]naphthyridinediones retain the Top1 inhibitory activity of similarly substituted indenoisoquinolines.

SUBMITTER: Kiselev E 

PROVIDER: S-EPMC3370419 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation.

Kiselev Evgeny E   Empey Nicholas N   Agama Keli K   Pommier Yves Y   Cushman Mark M  

The Journal of organic chemistry 20120515 11


Dibenzo[c,h][1,5]naphthyridinediones were prepared via a novel synthetic pathway. The compounds were designed as topoisomerase I (Top1) inhibitors based on the indenoisoquinoline series of drugs. The results of biological evaluation demonstrate that, unlike very closely related dibenzo[c,h][1,6]naphthyridinediones, dibenzo[c,h][1,5]naphthyridinediones retain the Top1 inhibitory activity of similarly substituted indenoisoquinolines. ...[more]

Similar Datasets

| S-EPMC2538619 | biostudies-literature
| S-EPMC3064471 | biostudies-literature
| S-EPMC6072309 | biostudies-literature
| S-EPMC4033654 | biostudies-literature
| S-EPMC6179045 | biostudies-literature
| S-EPMC2838169 | biostudies-literature
| S-EPMC11324053 | biostudies-literature
| S-EPMC8842116 | biostudies-literature
| S-EPMC8274952 | biostudies-literature
| S-EPMC4558194 | biostudies-literature