Ontology highlight
ABSTRACT:
SUBMITTER: Yu LM
PROVIDER: S-EPMC4558194 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20150708
In our previous work, indolizinoquinolinedione derivative 1 was identified as a Top1 catalytic inhibitor. Herein, a series of 6-substituted indolizinoquinolinedione derivatives were synthesized through modification of the parent compound 1. Top1 cleavage and relaxation assays indicate that none of these novel compounds act as classical Top1 poison, and that the compounds with alkylamino terminus at C-6 side chain, including 8, 11-16, 18-21, 25, 26 and 28-30, are the most potent Top1 catalytic in ...[more]